Bayer Leverkusen and Tottenham Hotspur shared the spoils in a goalless draw at the BayArena that saw both sides come within a whisker of finding a breakthrough goal.
Leverkusen made the brighter start with Stefan Kiessling threatening — but Tottenham thought they had made the breakthrough with 10 minutes on the clock.
The London side fashioned a move that ended with Vincent Janssen rolling the ball home after it had been laid off by the in-form Son Heung-Min, returning to his old club, only for the offside flag to thwart him.
A raucous home crowd cheered every challenge by one of their players, with Charles Aranguiz and Kevin Kampl making plenty as Spurs tried to lift the tempo.
After 21 minutes Erik Lamela found Kieran Trippier in space, only for the defender to produce a poor cross, with Hakan Calhanoglu booked for a poor challenge on Victor Wanyama soon afterwards.
But Spurs were gradually stepping up the pace and were within a whisker of breaking through when Dele Alli arrived to meet Tripper’s cross with a bullet header, only to see his effort fizz wide.
And Mauricio Pochettino’s side were left wondering how they had failed to open the scoring five minutes before the break when Alli’s shot was superbly blocked before Janssen headed Trippier’s follow-up cross against the bar and Lamela saw his acrobatic effort on the rebound tipped over superbly by Bernd Leno.
Three minutes after the break, it was Leverkusen’s turn to be denied when Hugo Lloris produced a stunning stop to repel a Javier Hernandez flick almost on the line after Spurs had failed to deal with a cross.
Hernandez and his teammates appealed in vain that the ball had crossed the line, and the same player went close again when Danny Rose bravely deflected his volley up and over the bar.
Lloris stopped an Aranguiz free-kick and, as the pressure from the home side grew, Pochettino took off striker Janssen and replaced him with Mousa Dembele shortly after the hour mark.
As Leverkusen continued to take the game to their visitors, Pochettino made another change with Erik Lamela coming off to be replaced by Moussa Sissoko — but it did little to alter the pattern of the half.
Omer Toprak sent an effort from the edge of the area high over the top after Lloris had failed to deal convincingly with a cross before another home attack was brought to an end when Vertonghen was fouled inside his own area.
Stefan Kiessling had a late chance to snatch all three points but could only guide a driven cross wide of the mark with six minutes remaining as the spoils were shared.